Table 1.
Publications reporting DNA damage response gene polymorphisms and the risk of oral, pharyngeal and laryngeal cancer.
| Author (year) Country |
Ethnic Groups (n) | Recruitment Period | Control Source | Tumor Sites | Cases (n) | Controls (n) | Crude OR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| XPA 5′-UTR (A23G) | A/A | A/G | G/G | A/A | A/G | G/G | A/G vs. A/A | G/G vs. A/A | A/G + G/G vs. A/A | ||||
|
An J (2007)(An et al., 2007) USA |
C (829) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 110 | 360 | 359 | 128 | 346 | 380 | 1.21 (0.90–1.62) | 1.09 (0.82–1.47) | 1.15 (0.88–1.52) |
|
Bau DT (2007)(Bau et al., 2007) Taiwan |
A (259) | 1997–2005 | Healthy | Oral Cavity | 38 | 84 | 32 | 29 | 53 | 23 | 1.20 (0.66–2.18) | 1.06 (0.51–2.18) | 1.16 (0.66–2.05) |
|
Hall J (2007)(Hall et al., 2007) Romania, Poland, Russia, Slovakia and Czeck Republic |
C (1690) | 2000–2002 | Hospital | Oral cavity, pharynx, larynx | 75 | 247 | 275 | 294 | 1125 | 891 | 0.86 (0.33–1.69) | 1.20 (0.90–1.61) | 1.01 (0.77–1.33) |
|
Sugimura T (2006)(Sugimura et al., 2006) Japan |
A (363) | 1988–2004 | Hospital | Oral cavity | 23 | 65 | 34 | 74 | 105 | 62 | 1.99 (1.13–3.49) | 1.76 (0.94–3.30) | 1.91 (1.12–3.24) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 30 | 109 | 107 | 72 | 281 | 291 | 0.93 (0.59–1.50) | 0.88 (0.55–1.43) | 0.91 (0.58–1.43) |
| META | 1.15 (0.96–1.36) | 1.12 (0.95–1.32) | |||||||||||
| P, Q test | 0.090 | 0.523 | 0.260 | ||||||||||
| P, Eggers test | 0.441 | 0.867 | 0.546 | ||||||||||
|
XPD Exon 6 C22541A Codon 156 |
C/C | C/A | A/A | C/C | C/A | A/A | C/A vs. C/C | A/A vs. C/C | C/A + AA vs. C/C | ||||
|
Majumder M (2007)(Majumder et al., 2007) India |
A (699) | 1999–2005 | Healthy | Oral cavity | 88 | 156 | 64 | 124 | 191 | 73 | 1.52 (0.91–2.56) | 0.82 (0.34–1.95) | 1.36 (0.82–2.22) |
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 45 | 52 | 9 | 82 | 62 | 20 | 1.15 (0.81–1.62) | 1.23 (0.80–1.90) | 1.17 (0.85–1.63) |
| Sturgis EM (2000)(Sturgis et al., 2000) | NHW(685) | 1995–1999 | Healthy | Oral cavity, pharynx, hypopharynx | 62 | 97 | 30 | 154 | 241 | 101 | 0.99 (0.68–1.45) | 0.73 (0.44–1.22) | 0.92 (0.64–1.32) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 79 | 28 | 41 | 199 | 309 | 139 | 1.04 (0.74–1.45) | 0.74 (0.48–1.14) | 0.95 (0.69–1.30) |
|
Rydzanicz M (2005)(Rydzanicz et al., 2005) Poland |
C (325) | --- | Healthy | Oral cavity and larynx | 73 | 82 | 26 | 54 | 69 | 20 | 0.88 (0.55–1.41) | 0.96 (0.49–1.90) | 0.90 (0.57–1.41) |
|
Gajecka M (2005)(Gajecka et al., 2005b) Poland |
C (615) | --- | Healthy | Larynx | 127 | 127 | 32 | 105 | 171 | 43 | 0.61 (0.43–0.87) | 0.62 (0.36–1.04) | 0.61 (0.44–0.85) |
| META | 0.84 (0.68–1.04) | ||||||||||||
| P, Q test | 0.052 | 0.402 | 0.067 | ||||||||||
| P, Eggers test | 0.467 | 0.841 | 0.495 | ||||||||||
|
XPD Exon 23 A35931C Codon 751 |
A/A | A/C | C/C | A/A | A/C | C/C | A/C vs. A/A | C/C vs. A/A | A/C + C/C vs. A/A | ||||
|
An J (2007)(An et al., 2007) USA |
C (829) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 330 | 394 | 105 | 358 | 386 | 110 | 1.10 (0.90–1.35) | 1.03 (0.76–1.40) | 1.09 (0.90–1.33) |
|
Bau DT (2007)(Bau et al., 2007) Taiwan |
A (259) | 1997–2005 | Healthy | Oral cavity | 134 | 18 | 2 | 89 | 15 | 1 | 0.79 (0.38–1.66) | 1.32 (0.11–14.86) | 0.83 (0.41–1.69) |
|
Hart V (2008)(Harth et al., 2008) Germany |
C (612) | 1996–1998 | Healthy | Oral cavity, pharynx, larynx | 111 | 154 | 47 | 108 | 149 | 43 | 1.00 (0.71–1.42) | 1.06 (0.65–1.73) | 1.02 (0.73–1.42) |
| Huang WY (2005)(Huang et al., 2005) | W (2,250) B (258) O (186) |
1997–2006 | Healthy | Oral cavity, pharynx, larynx | 240 | 235 | 69 | 345 | 325 | 105 | 1.03 (0.82–1.31) | 0.94 (0.66–1.33) | 1.02 (0.82–1.27) |
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 83 | 21 | 1 | 126 | 36 | 2 | 0.88 (0.48–1.62) | 0.75 (0.06–8.5) | 0.88 (0.49–1.59) |
|
Majumder M (2007)(Majumder et al., 2007) India |
A (699) | 1999–2005 | Healthy | Oral cavity | 158 | 125 | 26 | 190 | 158 | 40 | 0.95 (0.69–1.30) | 0.78 (0.45–1.33) | 0.92 (0.68–1.24) |
|
Ramachandran S((2006),Ramachandran et al., 2006) India |
A (220) | --- | Healthy | Oral cavity | 49 | 46 | 15 | 71 | 31 | 8 | 2.15 (1.20–3.85) | 2.71 (1.06–6.90) | 2.27 (1.32–3.90) |
|
Sturgis EM (2000)(Sturgis et al., 2000) USA |
NHW (685) | 1995–1999 | Healthy | Oral cavity, pharynx, hypopharynx | 75 | 83 | 31 | 218 | 221 | 57 | 1.09 (0.75–1.57) | 1.58 (0.94–2.63) | 1.19 (0.85–1.68) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 95 | 117 | 34 | 250 | 280 | 114 | 1.09 (0.79–1.51) | 0.78 (0.50–1.23) | 1.01 (0.75–1.36) |
| Matullo G (2006)(Matullo et al., 2006) France, Italy, Spain, United Kingdom, The Nederlands, Greece, Germany, Denmark |
C (1176) | 1993–1998 | Healthy | Oral cavity, pharynx, larynx | 34 | 29 | 9 | 397 | 504 | 193 | 0.90 (0.56–1.45) | 0.54 (0.25–1.15) | 0.80 (0.51–1.27) |
|
Rydzanicz M (2005)(Rydzanicz et al., 2005) Poland |
C (325) | --- | Healthy | Oral cavity, larynx | 0.89 (0.55–1.46) | 0.94 (0.50–1.78) | 0.91 (0.57–1.43) | ||||||
|
Gajecka M (2005)(Gajecka et al., 2005b) Poland |
C (615) | --- | Healthy | Larynx | 0.61 (0.43–0.87) | 0.65 (0.41–1.05) | 0.62 (0.44–0.87) | ||||||
| META | 1.01 (0.91–1.12) | 0.96 (0.82–1.11) | |||||||||||
| P, Q test | 0.126 | 0.184 | 0.000 | ||||||||||
| P, Eggers test | 0.719 | 0.720 | 0.446 | ||||||||||
| XPD Asp312Asn | G/G | G/A | A/A | G/G | G/A | A/A | G/A vs. G/G | A/A vs. G/G | G/A + A/A vs. G/G | ||||
|
An J (2007)(An et al., 2007) USA |
C (771) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 330 | 395 | 104 | 370 | 386 | 98 | 1.14 (0.93–1.40) | 1.18 (0.86–1.62) | 1.16 (0.95–1.40) |
|
Hart V (2008)(Harth et al., 2008) Germany |
C (612) | 1996–1998 | Healthy | Oral cavity, pharynx, larynx | 113 | 158 | 40 | 101 | 145 | 52 | 0.97 (0.68–1.38) | 0.68 (0.42–1.12) | 0.90 (0.64–1.25) |
|
Majumder M (2007)(Majumder et al., 2007) India |
A (699) | 1999–2005 | Healthy | Oral cavity | 152 | 119 | 34 | 205 | 146 | 36 | 1.09 (0.79–1.51) | 1.27 (0.76–2.12) | 1.13 (0.84–1.53) |
|
Sturgis EM (2002a)(Sturgis et al., 2002b) USA |
NHW (626) | 1995–2001 | Healthy | Oral cavity, pharynx, larynx | 123 | 165 | 25 | 142 | 135 | 36 | 1.41 (1.01–1.96) | 0.80 (0.45–1.40) | 1.28 (0.93–1.76) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 93 | 119 | 34 | 258 | 304 | 82 | 1.08 (0.79–1.49) | 1.15 (0.72–1.83) | 1.10 (0.81–1.49) |
| Matullo G (2006)(Matullo et al., 2006) France, Italy, Spain, United Kingdom, The Nederlands, Greece, Germany, Denmark |
C (1176) | 1993–1998 | Healthy | Oral, pharyngeal, laryngeal | 32 | 46 | 4 | 418 | 506 | 170 | 1.18 (0.74–1.89) | 0.30 (0.10–0.88) | 0.97 (0.61–1.53) |
| META | 1.14 (1.01–1.29) | 1.11 (0.99–1.25) | |||||||||||
| P, Q test | 0.772 | 0.075 | 0.717 | ||||||||||
| P, Eggers test | 0.987 | 0.100 | 0.350 | ||||||||||
| XPD Exon 8 C23047G | C/C | C/G | G/G | C/C | C/G | G/G | C/G vs. C/C | G/G vs. C/C | C/G + G/G vs. C/C | ||||
|
Sturgis EM (2002b)(Sturgis et al., 2002a) USA |
NHW (580) | 1995–1998 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 179 | 0 | 1 | 393 | 7 | 0 | --- | --- | 0.31 (0.03–2.57) |
| XPD Exon 8 C23051G | C/C | C/G | G/G | C/C | C/G | G/G | C/G vs. C/C | C/G vs. C/C | C/G + G/G vs. C/C | ||||
|
Sturgis EM (2002b)(Sturgis et al., 2002a) USA |
NHW (580) | 1995–1998 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 24 | 2 | 0 | 110 | 5 | 0 | --- | --- | 6.70 (0.27–165.11) |
| XPC PAT | +/+ | +/− | −/− | +/+ | +/− | −/− | +/− vs. +/+ | −/− vs. +/+ | (+/−) + (−/−) vs. +/+ | ||||
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 60 | 36 | 10 | 89 | 66 | 9 | 0.80 (0.48–1.36) | 1.64 (0.63–4.29) | 0.91 (0.56–1.49) |
|
Shen H (2001)(Shen et al., 2001) USA |
NHW (294) AA (178) HA (103) NCh (109) |
1995–1999 | Healthy | Oral cavity, pharynx, larynx | 102 | 135 | 50 | 141 | 133 | 37 | 1.40 (0.98–1.99) | 1.86 (1.13–3.06) | 1.50 (1.08–2.09) |
|
Sugimura T (2006)(Sugimura et al., 2006) Japan |
A (363) | 1988–2004 | Hospital | Oral cavity | 42 | 63 | 17 | 78 | 128 | 35 | 0.91 (0.56–1.47) | 0.90 (0.45–1.79) | 0.91 (0.57–1.44) |
|
Yang M (2005)(Yang et al., 2005) South Korea |
A (155) | --- | Hospital | Oral cavity, oro/hypopharynx, larynx | 35 | 29 | 9 | 38 | 33 | 11 | 0.95 (0.48–1.87) | 0.88 (0.32–2.39) | 0.94 (0.50–1.76) |
| META | 1.09 (0.86–1.37) | 1.39 (0.99–1.97) | 1.14 (0.92–1.43) | ||||||||||
| P, Q test | 0.270 | 0.287 | 0.186 | ||||||||||
| P, Eggers test | 0.205 | 0.441 | 0.134 | ||||||||||
|
XPC Exon 15 Lys939Gln |
Lys/Lys | Lys/Gln | Gln/Gln | Lys/Lys | Lys/Gln | Gln/Gln | Lys/Gln vs. Lys/Lys | Gln/Gln vs. Lys/Lys | Lys/Gln + Gln/Gln vs. Lys/Lys | ||||
|
An J (2007)(An et al., 2007) USA |
C (771) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 312 | 339 | 118 | 315 | 425 | 114 | 0.94 (0.77–1.16) | 1.10 (0.90–1.34) | 0.97 (0.79–1.18) |
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 59 | 37 | 10 | 87 | 67 | 10 | 0.81 (0.48–1.36) | 0.85 (0.61–1.19) | 0.90 (0.55–1.47) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 83 | 120 | 45 | 230 | 329 | 88 | 1.01 (0.73–1.40) | 1.41 (0.91–2.19) | 1.10 (0.81–1.49) |
| META | 0.94 (0.80–1.12) | 1.17 (0.92–1.49) | 0.99 (0.85–1.16) | ||||||||||
| P, Q test | 0.787 | 0.470 | 0.737 | ||||||||||
| P, Eggers test | 0.661 | 0.467 | 0.987 | ||||||||||
| XPC Exon 15 Ala499Val | Ala/Ala | Ala/Val | Val/Val | Ala/Ala | Ala/Val | Val/Val | Ala/Val vs. Ala/Ala | Val/Val vs. Ala/Ala | Ala/Val + Val/Val vs. Ala/Ala | ||||
|
An J (2007)(An et al., 2007) USA |
C (771) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 455 | 293 | 91 | 454 | 342 | 58 | 0.85 (0.69–1.04) | 1.56 (1.09–2.23) | 0.96 (0.79–1.16) |
| XPF 5′-UTR (T2063A) | T/T | T/A | A/A | T/T | T/A | A/A | T/A vs. T/T | A/A vs. T/T | T/A + A/A vs. T/T | ||||
|
Sugimura T (2006)(Sugimura et al., 2006) Japan |
A (363) | 1988–2004 | Hospital | Oral cavity | 66 | 47 | 9 | 119 | 101 | 21 | 0.83 (0.53–1.33) | 0.77 (0.33–1.78) | 0.83 (0.53–1.28) |
|
ERCC1 3′UTR C 8092A |
C/C | C/A | A/A | C/C | C/A | A/A | C/A vs. C/C | A/A vs. C/C | C/A + A/A vs. C/C | ||||
|
An J (2007)(An et al., 2007) USA |
C (771) | 1995–2005 | Hospital | Oral cavity, pharynx, larynx | 455 | 326 | 48 | 485 | 315 | 54 | 1.10 (0.90–1.34) | 0.94 (0.62–1.42) | 1.08 (0.89–1.31) |
|
Sturgis EM (2002a)(Sturgis et al., 2002b) USA |
NHW (685) | 1995–1999 | Healthy | Oral cavity, pharynx, larynx | 183 | 116 | 14 | 172 | 127 | 14 | 0.85 (0.61–1.19) | 0.93 (0.43–2.02) | 0.87 (0.63–1.19) |
|
Sugimura T (2006)(Sugimura et al., 2006) Japan |
A (363) | 1988–2004 | Hospital | Oral cavity | 75 | 30 | 17 | 130 | 94 | 17 | 0.55 (0.33–0.91) | 1.73 (0.83–3.59) | 0.73 (0.47–1.14) |
|
Abbasi R (2009)(Abbasi et al., 2009) Germany |
C (1026) | 1998–2000 | Healthy | Larynx | 146 | 87 | 15 | 392 | 218 | 37 | 1.07 (0.78–1.46) | 1.08 (0.58–2.04) | 1.07 (0.80–1.45) |
| META | 1.07 (0.80–1.43) | 1.00 (0.87–1.14) | |||||||||||
| P, Q test | 0.063 | 0.546 | 0.322 | ||||||||||
| P, Eggers test | 0.112 | 0.420 | |||||||||||
| XRCC1 Exon 6 Codon 194 | C/C | C/T | T/T | C/C | C/T | T/T | C/T vs. C/C | T/T vs. C/C | C/T + T/T vs. C/C | ||||
|
Demokan S (2005)(Demokan et al., 2005) Turkey |
A (1936) | --- | Healthy | Oral cavity | 78 | 14 | 3 | 88 | 8 | 2 | 1.97 (0.78–4.95) | 1.69 (0.27–10.39) | 1.92 (0.83–4.44) |
|
Hart V (2008)(Harth et al., 2008) Germany |
C (612) | 1996–1998 | Healthy | Oral cavity, pharynx, larynx | 217 | 40 | 1 | 259 | 39 | 2 | 1.22 (0.76–1.97) | 0.59 (0.05–6.62) | 1.19 (0.75–1.91) |
|
Kowalski M (2009)(Kowalski et al., 2009) Poland |
C (216) | --- | Hospital | Head and neck cancr/NOS | 71 | 21 | 0 | 102 | 22 | 0 | 1.37 (0.70–2.98) | --- | 1.37 (0.70–2.68) |
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 40 | 50 | 16 | 77 | 67 | 20 | 1.43 (0.84–2.43) | 1.54 (0.71–3.29) | 1.46 (0.89–2.40) |
|
Majumder M (2005)(Majumder et al., 2005) India |
A (658) | 1999–2004 | Healthy | Oral cavity | 249 | 58 | 3 | 285 | 57 | 6 | 1.16 (0.77–1.74) | 0.57 (0.14–2.31) | 1.11 (0.75–1.64) |
|
Olshan AF (2002)(Olshan et al., 2002) USA |
--- | 1994–1997 | Hospital | Oral cavity, pharynx, larynx | 82 | 16 | 0 | 135 | 26 | 0 | 1.01 (0.51–2.00) | --- | 1.01 (0.51–2.00) |
|
Ramachandran S((2006),Ramachandran et al., 2006) India |
A (220) | --- | Healthy | Oral cavity | 66 | 37 | 7 | 90 | 19 | 1 | 2.65 (1.40–5.02) | 9.54 (1.14–79.46) | 3.00 (1.62–5.56) |
|
Sturgis EM (1999)(Sturgis et al., 1999) USA |
NHW (565) MA (39) AA (23) |
1995–1998 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 180 | 22 | 1 | 363 | 61 | 0 | 0.72 (0.43–1.22) | 6.04 (0.24–149.04) | 0.76 (0.46–1.27) |
|
Tae K (2004)(Tae et al., 2004) Korea |
A (315) | 1997–2001 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 59 | 52 | 9 | 101 | 39 | 5 | 2.28 (1.35–3.85) | 3.08 (0.98–9.62) | 2.37 (1.43–3.93) |
|
Yen CY (2008)(Yen et al., 2008) Taiwan |
A (2010) | --- | Hospital | Oral squamous cell carcinoma/NOS | 48 | 40 | 15 | 54 | 35 | 9 | 1.28 (0.70–2.33) | 1.87 (0.75–4.67) | 1.41 (0.81–2.45) |
|
Varzim G (2003)(Varzim et al., 2003) Portugal |
C (266) | 1998–1999 | Healthy | Larynx | 80 | 8 | 0 | 160 | 18 | 0 | 0.88 (0.37–2.13) | --- | 0.89 (0.37–2.13) |
| Matullo G (2006)(Matullo et al., 2006) France, Italy, Spain, United Kingdom, The Nederlands, Greece, Germany, Denmark |
C (1176) | 1993–1998 | Healthy | Oral cavity, pharynx, larynx | 78 | 4 | 0 | 951 | 141 | 2 | 0.34 (1.24–0.96) | 2.42 (0.11–50.93) | 0.34 (0.12–0.95) |
|
Rydzanicz M (2005)(Rydzanicz et al., 2005) Poland |
C (325) | --- | Healthy | Oral cavity and larynx | 165 | 16 | 1 | 129 | 14 | 0 | 0.89 (0.42–1.90) | 2.35 (0.09–58.10) | 0.95 (0.45–2.00) |
|
Csejtei A (2009)(Csejtei et al., 2009) Hungary |
C (211) | 2000–2003 | Healthy | Head and neck cancer/NOS | 96 | 11 | 1 | 85 | 15 | 2 | 0.65 (0.28–1.49) | 0.44 (0.04–4.97) | 0.63 (0.28–1.38) |
|
Gajecka M (2005)(Gajecka et al., 2005b) Poland |
C (615) | --- | Healthy | Larynx | 262 | 27 | 1 | 291 | 33 | 1 | 0.91 (0.53–1.55) | 1.11 (0.07–17.85) | 0.91 (0.54–1.55) |
| META | 1.69 (1.10–2.58) | ||||||||||||
| P, Q test | 0.018 | 0.646 | 0.005 | ||||||||||
| P, Eggers test | 0.621 | 0.902 | 0.535 | ||||||||||
|
XRCC1 Exon 10 Codon 399 |
G/G | G/A | A/A | G/G | G/A | A/A | G/A vs. G/G | A/A vs. G/G | G/A + A/A vs. G/G | ||||
|
Demokan S (2005)(Demokan et al., 2005) Turkey |
A (1936) | --- | Healthy | Oral cavity | 42 | 41 | 12 | 39 | 46 | 13 | 0.82 (0.45–1.51) | 0.85 (0.34–2.10) | 0.83 (0.47–1.48) |
|
Hart V (2008)(Harth et al., 2008) Germany |
C (612) | 1996–1998 | Healthy | Oral cavity, pharynx, larynx | 114 | 166 | 30 | 143 | 121 | 36 | 1.72 (1.22–2.41) | 1.04 (0.60–1.79) | 1.57 (1.13–2.16) |
| Huang WY (2005)(Huang et al., 2005) | W (2,250) B (258) O (186) |
1997–2006 | Healthy | Oral cavity, pharynx, larynx | 266 | 219 | 40 | 338 | 338 | 81 | 0.82 (0.65–1.04) | 0.62 (0.41–0.94) | 0.79 (0.63–0.98) |
|
Kowalski M (2009)(Kowalski et al., 2009) Poland |
C (216) | --- | Hospital | Head and neck cancer/NOS | 37 | 44 | 11 | 49 | 53 | 22 | 1.09 (0.61–1.97) | 0.66 (0.28–1.53) | 0.97 (0.56–1.68) |
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 55 | 45 | 6 | 67 | 74 | 23 | 0.74 (0.44–1.23) | 0.31 (0.12–0.83) | 0.64 (0.39–1.05) |
|
Majumder M (2005)(Majumder et al., 2005) India |
A (658) | 1999–2004 | Healthy | Oral cavity | 135 | 143 | 32 | 158 | 163 | 27 | 1.02 (0.84–1.28) | 1.38 (0.79–2.43) | 1.08 (0.79–1.47) |
| Li C (2007)(Li et al., 2007) | NHW (1684) | 1995–2003 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 335 | 374 | 121 | 360 | 385 | 109 | 1.04 (0.84–1.28) | 1.19 (0.88–1.60) | 1.08 (0.89–1.31) |
|
Ramachandran S((2006),Ramachandran et al., 2006) India |
A (220) | --- | Healthy | Oral cavity | 46 | 48 | 16 | 73 | 33 | 4 | 2.30 (1.29–4.10) | 6.34 (1.99–20.17) | 2.75 (1.59–4.75) |
|
Sturgis EM (1999)(Sturgis et al., 1999) USA |
NHW (565) MA (39) AA (23) |
1995–1998 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 94 | 77 | 32 | 181 | 197 | 46 | 0.75 (0.52–1.08) | 1.33 (0.80–2.24) | 0.86 (0.62–1.21) |
|
Tae K (2004)(Tae et al., 2004) Korea |
A (315) | 1997–2001 | Hospital | Oral cavity, oro/hypopha rynx, larynx | 69 | 51 | 9 | 86 | 64 | 7 | 0.99 (0.611–1.61) | 1.60 (0.56–4.52) | 1.05 (0.66–1.68) |
|
Varzim G (2003)(Varzim et al., 2003) Portugal |
C (266 | 1998–1999 | Healthy | Larynx | 37 | 40 | 11 | 80 | 80 | 18 | 1.08 (0.62–1.86) | 1.32 (0.56–4.07) | 1.13 (0.67–1.89) |
| Matullo G (2006)(Matullo et al., 2006) France, Italy, Spain, United Kingdom, The Nederlands, Greece, Germany, Denmark |
C (1176) | 1993–1998 | Healthy | Oral cavity, pharynx, larynx | 34 | 38 | 10 | 484 | 482 | 128 | 1.02 (0.92–1.12) | 1.11 (0.53–2.31) | 1.12 (0.71–1.77) |
|
Rydzanicz M (2005)(Rydzanicz et al., 2005) Poland |
C (325) | --- | Healthy | Oral cavity and larynx | 63 | 98 | 21 | 59 | 63 | 21 | 1.46 (0.91–2.34) | 0.13 (0.05–0.33) | 1.33 (0.84–2.08) |
|
Csejtei A (2009)(Csejtei et al., 2009) Hungary |
C (211) | 2000–2003 | Healthy | Head and neck cancer/NOS | 50 | 47 | 11 | 53 | 41 | 8 | 1.22 (0.69–2.15) | 1.46 (0.54–3.92) | 1.25 (0.73–2.16) |
|
Gajecka M (2005)(Gajecka et al., 2005b) Poland |
C (615) | --- | Healthy | Larynx | 106 | 153 | 34 | 124 | 145 | 50 | 1.23 (0.87–1.74) | 0.80 (0.48–1.32) | 1.12 (0.81–1.56) |
| META | |||||||||||||
| P, Q test | 0.014 | 0.000 | 0.004 | ||||||||||
| P, Eggers test | 0.360 | 0.868 | 0.355 | ||||||||||
| XRCC1 Exon 9 Codon 280 | G/G | G/A | A/A | G/G | G/A | A/A | G/A vs. G/G | A/A vs. G/G | G/A + A/A vs. G/G | ||||
|
Hart V (2008)(Harth et al., 2008) Germany |
C (612) | 1996–1998 | Healthy | Oral cavity, pharynx, larynx | 283 | 28 | 1 | 270 | 30 | 0 | 0.89 (0.51–1.53) | 2.86 (0.11–70.57) | 0.92 (0.54–1.58) |
|
Majumder M (2005)(Majumder et al., 2005) India |
A (658) | 1999–2004 | Healthy | Oral cavity | 228 | 79 | 3 | 264 | 81 | 3 | 1.12 (0.79–1.61) | 1.15 (0.23–5.79) | 1.13 (0.79–1.61) |
|
Ramachandran S((2006),Ramachandran et al., 2006) India |
A (220) | --- | Healthy | Oral cavity | 77 | 31 | 2 | 83 | 26 | 1 | 1.28 (0.70–2.35) | 2.15 (0.19–24.25) | 1.32 (0.73–2.39) |
|
Tae K (2004)(Tae et al., 2004) Korea |
A (315) | 1997–2001 | Hospital | Oral cavity, oro/hypopha rynx, larynx |
113 | 21 | 1 | 139 | 29 | 0 | 0.89 (0.48–1.64) | 3.68 (0.14–91.38) | 0.93 (0.51–1.71) |
| META | 1.06 (0.83–1.35) | 1.74 (0.55–5.52) | 1.08 (0.85–1.37) | ||||||||||
| P, Q test | 0.749 | 0.901 | 0.790 | ||||||||||
| P, Eggers test | 0.648 | 0.003 | 0.737 | ||||||||||
| XRCC3 Thr241Met | Thr/Thr | Thr/Met | Met/Me t | Thr/Thr | Thr/Met | Met/Met | Thr/Met vs. Thr/Thr | Met/Met vs. Thr/Thr | Thr/Met + Met/Met vs. Thr/Thr | ||||
|
Kietthubthew S (2006)(Kietthubthew et al., 2006) Thai |
A (304) | 1998–1999 | Hospital | Oral cavity | 83 | 22 | 1 | 140 | 23 | 1 | 1.61 (0.84–3.07) | 1.68 (0.10–27.32) | 1.62 (0.86–3.04) |
|
Majumder M (2005)(Manuguerra et al., 2006) India |
A (658) | 1999–2004 | Healthy | Oral cavity | 201 | 97 | 12 | 220 | 120 | 8 | 0.88 (0.63–1.22) | 1.09 (0.48–2.49) | 0.90 (0.66–1.24) |
| Huang WY (2005)(Huang et al., 2005) | W (2,250) B (258) O (186) |
1997–2006 | Healthy | Oral cavity, pharynx, larynx | 232 | 223 | 61 | 329 | 334 | 97 | 0.94 (0.74–1.20) | 1.41 (0.95–2.10) | 1.02 (0.81–1.28) |
|
Yen CY (2008)(Yen et al., 2008) Taiwan |
A (2010 | --- | Hospital | Oral squamous cell carcinoma/NOS | 96 | 7 | 0 | 89 | 9 | 0 | 0.72 (0.25–2.01) | --- | 0.72 (0.26–2.02) |
|
Werbrouck J (2008)(Werbrouck et al., 2008) Belgium |
C (309) | 2004–2006 | Healthy | Oral cavity, pharynx, larynx | 69 | 59 | 29 | 44 | 75 | 33 | 0.50 (0.30–0.83) | 0.63 (0.33–1.20) | 0.54 (0.34–0.87) |
|
Benhamou S (2004)(Benhamou et al., 2004) France |
C (422) | 1988–1992 | Healthy | Oral cavity, pharynx, larynx | 42 | 54 | 23 | 47 | 89 | 30 | 0.67 (0.39–1.16) | 1.11 (0.54–2.28) | 0.77 (0.46–1.28) |
| Matullo G (2006)(Matullo et al., 2006) France, Italy, Spain, United Kingdom, The Nederlands, Greece, Germany, Denmark |
C (1176) | 1993–1998 | Healthy | Oral cavity, pharynx, larynx | 29 | 39 | 14 | 383 | 544 | 167 | 0.95 (0.58–1.56) | 1.11 (0.57–2.15) | 0.98 (0.62–1.57) |
|
Rydzanicz M (2005)(Rydzanicz et al., 2005) Poland |
C (325) | --- | Healthy | Oral cavity, larynx | 22 | 71 | 89 | 14 | 71 | 58 | 0.64 (0.30–1.34) | 0.98 (0.46–2.06) | 0.79 (0.39–1.60) |
|
Gajecka M (2005)(Gajecka et al., 2005b) Poland |
C (615) | --- | Healthy | Larynx | 135 | 125 | 33 | 144 | 131 | 47 | 1.02 (1.72–1.43 | 0.75 (0.45–1.24) | 0.95 (0.69–1.30) |
| Shen H (2002)(Shen et al., 2002) USA |
NHW (721) | 1995–2001 | Healthy | Oral cavity, pharynx, larynx | 150 | 159 | 58 | 141 | 170 | 43 | 0.88 (0.64–1.21) | 1.27 (0.80–2.00) | 0.96 (0.71–1.29) |
| META | 0.89 (0.78–1.01) | 1.07 (0.88–1.31) | 0.93 (0.82–1.05) | ||||||||||
| P, Q test | 0.277 | 0.521 | 0.370 | ||||||||||
| P, Eggers test | 0.457 | 0.641 | 0.486 | ||||||||||
Abbreviations: C= Caucasians, A= Asians, NHW= Non-Hispanic whites, MA= Mexican-Americans, AA= African-Americans, HA= Hispanic-Americans, NCh= Native Chinese, B= Black, O= Others, NOS= not otherwise specified,