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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Surgery. 2010 Jun 8;148(2):453–462. doi: 10.1016/j.surg.2010.04.013

Figure 7. Summary Figure. Schematic representation of angiogenic and anti-angiogenic pathways modified by high cholesterol and or resveratrol.

Figure 7

Proteins modified by high cholesterol are indicated with solid black arrows. Modification of specific pathways by resveratrol are indicated by small dashed arrows. Resveratrol appears to act by increasing angiostatin, and does not change the increase in thrombospondin associated with metabolic syndrome. The overall effect of these integrated anti-angiogenic signals potentially acts to decrease vascular tube formation resulting in decreased vessel formation in the ischemic myocardium.