Figure 1. Deoxyribozyme based molecular walker and origami prescriptive landscape schematics.

a, The NICK3.4A₃₊₁ spider consists of a streptavidin core that displays a 20 base ssDNA that positions the spider at the start (green), and three deoxyribozyme legs. b, The 8-17 deoxyribozyme cleaves its substrate at an RNA base creating two shorter products (seven and eleven bases). Dissociation from these products allows legs to associate with the next substrate. c, Spider actions: after release by a 27-base ssDNA trigger, the spider follows the substrate track, turns, and continues to a stop site (red). d, Schematic of the DNA origami landscape with positions A-E labeled; track EABD is shown. e, A representative origami landscape shows the start position (green), the substrate track (brown), stop and control sites (red), and a topographical marker (blue),