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. 2010 May 26;1:5. doi: 10.1186/2041-9414-1-5

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Copyright ©2010 Gurung et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Telomere length measurements by Q-FISH in different cell types used. Frequency distributions of telomere fluorescence in mTERC^+/+and mTERC^-/-MEFs from Q-FISH studies on metaphases prepared from surviving cells following treatment with PARP inhibitor and arsenite. Average telomere fluorescence intensity was significantly lower (⁺p < 0.05) in untreated mTERC^-/-as compared to untreated mTERC^+/+cells. Arsenite treatment led to significant decrease (*p < 0.05) in average mean telomere florescence intensity in both mTERC^+/+cells and mTERC^-/-cell as compared to respective untreated controls. Changes in distribution of frequency of cells with shorter telomere fluorescence intensity observed following treatment with 3-AB and arsenite in both mTERC^+/+and mTERC^-/-cells.