Table 2.

Pathological Evaluation of ERG Protein Expression Versus ERG Rearrangement Status as Determined by FISH in Cohorts from the WCMC and the UM Cohorts.

	ERG Status			Patient Cohort
Pathologist evaluation		Positive	Negative	Combined	Sensitivity	95.7%
	Positive	88	4		Specificity	96.5%
	Negative	4	111		PPV	95.7%
					NPV	96.5%
	Fisher = 6.07e - 48
Pathologist evaluation		Positive	Negative	WCMC	Sensitivity	100.0%
	Positive	60	2		Specificity	97.1%
	Negative	0	66		PPV	96.8%
					NPV	100.0%
	Fisher = 1.01e - 34
Pathologist evaluation		Positive	Negative	UM	Sensitivity	87.5%
	Positive	28	2		Specificity	95.7%
	Negative	4	45		PPV	93.3%
					NPV	91.8%
	Fisher = 7.05e - 15

ERG FISH: negative versus positive (insertion + deletion); IHC: negative versus (weak + moderate + strong). Note that for the WCMC cohort, 128 cases were evaluated.