Table 1.

Pylorus-preserving pancreaticoduodenectomy versus Kausch–Whipple pancreaticoduodenectomy

Ref	Study design	Population	Intervention and comparison	Co-interventions	Outcome	Time	Comment
	Systematic review (32 studies)	2822 people having PPPD or KW	PPPD v KW		Perioperative mortality:22 studies; 2049 people; 24/1035 (2%) with PPPD v 44/1014 (4%) with KW; OR 1.70, 95% CI 1.02 to 2.83; P = 0.04
					Overall survival:9 studies; 661 people; HR 0.66, 95% CI 0.51 to 0.86; P = 0.002; Heterogeneity 0.003	5 years
					Complications (overall morbidity):11 studies; 999 people; OR 0.89, 95% CI 0.62 to 1.28; P = 0.53
					Delayed gastric emptying:18 studies; 1698 people; OR 0.69, 95% CI 0.42 to 1.14; P = 0.15
					Haemorrhage:10 studies; 1061 people; OR 1.17, 95% CI 0.69 to 2.00; P = 0.56
					Pancreatic leak:6 studies; 662 people; OR 1.05, 95% CI 0.59 to 1.87; P = 0.87
					Pancreatic fistula:13 studies; 1199 people; OR 0.78, 95% CI 0.52 to 1.16; P = 0.22
					Biliary leak:6 studies; 741 people; OR 1.32, 95% CI 0.52 to 3.38; P = 0.56
					Biliary fistula:6 studies; 426 people; OR 1.28, 95% CI 0.41 to 3.98; P = 0.67
					Wound infections:14 studies; 1196 people; OR 0.83, 95% CI 0.51 to 1.35; P = 0.46
					Re-laparotomy: 6 studies; 715 people; OR 1.59, 95% CI 1.03 to 2.46; P = 0.04
	RCT included in review	130 people with resectable pancreatic cancer; tumour diameter 2.6–2.9 cm; 67% lymph node-positive; 82% R0 resection; mean age 65 years	PPPD v KW	All participants received octreotide and pancreaticojejunostomy; no-one received neoadjuvant chemoradiotherapy; no information on adjuvant treatment reported	QoL:Sickness impact scores (both physical and psychological) similar between PPPD and KW; P value not reported
	RCT included in review	48 people with resectable head of pancreas or peri-ampullary cancer	PPPD v KW	Details of anastomosis and use of octreotide not reported	Global QOL:No significant difference between groups at 60 weeks (measured by 100-point EORTC-QLQ-30 score); results presented graphically; score in both groups about 35; P greater than 0.05

FACT-G QOL, Functional Assessment of Cancer Therapy — ; KW, Kausch–Whipple pancreaticoduodenectomy; PPPD, pylorus-preserving pancreaticoduodenectomy; QoL, quality of life; Ref, reference. HR, hazard ratio.