Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	46 people Data from 1 RCT	Proportion of people withdrawing from an RCT 8 weeks 8/25 (32%) with amitriptyline 5/21 (25%) with placebo	RR 1.34 95% CI 0.52 to 3.49 Known adverse effects of tricyclic antidepressants include anticholinergic effects (see harms of prescription antidepressant drugs in review on depression in adults [drug and other physical treatments])		Not significant
Systematic review	41 people Data from 1 RCT	Proportion of people withdrawing from an RCT 8 weeks 12/23 (52%) with imipramine 12/18 (67%) with placebo	RR 0.78 95% CI 0.47 to 1.3 Known adverse effects of tricyclic antidepressants include anticholinergic effects (see harms of prescription antidepressant drugs in review on depression in adults [drug and other physical treatments])		Not significant