Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Proportion of people with PTSD
RCT	41 people with early symptoms of PTSD 6 hours after a traumatic event	Proportion of people with PTSD (measured by Clinician Administered Post-traumatic Stress Disorder Scale) 1 month 2/11 (18%) with propranolol 40 mg four times daily for 10 days 6/20 (30%) with placebo	RR 0.52 95% CI 0.09 to 3.16 The follow-up of the RCT is 75%, which is slightly below our reporting criteria of 80%. However, because of the paucity of data on the effects of propranolol in the prevention of PTSD, we have decided to include this RCT		Not significant
RCT	41 people with early symptoms of PTSD 6 hours after a traumatic event	Proportion of people with PTSD (measured by Clinician Administered Post-traumatic Stress Disorder Scale) 3 months 1/11 (9%) with propranolol 40 mg four times daily for 10 days 2/15 (13%) with placebo	RR 0.65 95% CI 0.05 to 8.23 The follow-up of the RCT is 75%, which is slightly below our reporting criteria of 80%. However, because of the paucity of data on the effects of propranolol in the prevention of PTSD, we have decided to include this RCT		Not significant
RCT 3-armed trial	48 people admitted to a surgical trauma centre with severe injuries	Proportion of people diagnosed with PTSD (assessed using various scales) 4 months 3/12 (25%) with propranolol (initially 20 mg three times daily increasing to 40 mg three times daily) 4/16 (25%) with placebo	Significance not assessed People with and without risk factors for PTSD after injury were enrolled in the RCT The RCT may have been underpowered to detect clinically meaningful differences between groups