Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	66 people 2 RCTs in this analysis	Proportion of people withdrawing (any reason) 7/33 (21%) with fluoxetine 12/33 (36%) with placebo	RR 0.60 95% CI 0.28 to 1.30		Not significant
RCT	65 people In review	Nausea with fluoxetine with placebo Absolute results not reported	P <0.05	Effect size not calculated	placebo
RCT	65 people In review	Diarrhoea with fluoxetine with placebo Absolute results not reported	P <0.05	Effect size not calculated	placebo
RCT	65 people In review	Thirst with fluoxetine with placebo Absolute results not reported	P <0.05	Effect size not calculated	placebo
RCT 3-armed trial	411 people with chronic PTSD resulting from various traumatic events	Proportion of people withdrawing due to adverse effects 12 weeks (end of treatment) 4% with fluoxetine 20 mg daily (fixed dose) 13% with fluoxetine 40 mg daily (fixed dose) 8% with placebo Absolute numbers not reported	P greater than 0.20 for both comparisons of fluoxetine versus placebo The number of people who withdrew from the RCT is unclear		Not significant