Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
PTSD symptoms
Systematic review	1123 people 6 RCTs in this analysis	Severity of clinician-rated symptoms of PTSD with sertraline with placebo Absolute results not reported	SMD –0.26 95% CI –0.51 to 0 Result is of borderline significance		Not significant
RCT	169 people with combat-related PTSD	Mean change in Clinician Administered PTSD Scale 12 weeks –13.1 with sertraline (25–200 mg/day, flexible dose) –15.4 with placebo	Reported as not significant P value not reported		Not significant