Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Quality of life
Systematic review	34 people Data from 1 RCT	Proportion of people improved on general health questionnaire 12/20 (60%) with levothyroxine 11/14 (78%) with placebo	RR 0.76 95% CI 0.49 to 1.20 P = 0.24		Not significant
Systematic review	31 people Data from 1 RCT	Changes in health-related quality of life with levothyroxine with placebo Absolute numbers not reported	SMD +0.08 95% CI –0.62 to +0.79 P = 0.98		Not significant