Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT Crossover design 3-armed trial	124 people; 91(73%) with episodic cluster headache, 33 (27%) with chronic cluster headache; 340 attacks in total	Adverse effects 37/111 (33%) with zolmitriptan 10 mg 25/114 (22%) with zolmitriptan 5 mg 15/115 (13%) with placebo	Significance not assessed
RCT Crossover design 3-armed trial	124 people; 91 (73%) with episodic cluster headache, 33 (27%) with chronic cluster headache; 340 attacks in total	Chest symptoms (including tightness, heaviness, or pressure) 4/111 (3.6%) with zolmitriptan 10 mg 1/114 (<1%) with zolmitriptan 5 mg 4/115 (3.5%) with placebo	Significance not assessed