Table 1.

Results of studies on mouse models

Animal model	Mouse strain	Locus	Result	Reference
Bleomycin	C57BL6	Chr 17	LOD score 2.8, marker D17Mit198/D17Mit16 localized to 2.7 cM region of MHC accounting for 40% of genetic risk	[28]
		Chr 11	LOD score 3.3, D11Mit272/D11Mit310 with evidence for interactions between Chr 17 and 11
Bleomycin	C57BL6 and A/J congenic	Chr 9	LOD 4.9 at D9Mit236, 246 differentially expressed genes mapped to the interval	[27]
Bleomycin	C3H-H2 reduced congenic	MHC susceptible	Reduced levels of bleomycin hydrolase activity in the fibrosis-prone strains	[29]
Radiation	C57BL/6J	Chr 17	LOD 4.2 at D17Mit16 within the bleomycin-linked region	[31]
		Chr 1	LOD 4.5 at D1Mit206
		Chr 6	LOD 4.6 at D6Mit254