. 2010 Jul 14;429(Pt 3):515–526. doi: 10.1042/BJ20091649

Table 1. PQQ status, body weight, liver/body weight ratio, plasma PQQ levels and liver mtDNA/nuclear DNA ratios.

PQQ+, values for rats fed on an ASD containing 2 mg/kg PQQ; PQQ−, values for rats fed on an ASD devoid of PQQ; PQQ+/−, values for rats subjected to a short-term PQQ depletion (48 h); PQQ−/+, values for rats subjected to a PQQ repletion via intraperitoneal injection at 1.5 mg of PQQ/kg of body weight every 12 h for a period of 36 h. The relative amounts of liver mitochondrial DNA (mtDNA) and nuclear DNA measured by real-time PCR. The targeted genes were the nuclear CF and the mitochondrial ND-5 gene. Values within each row labelled with differing superscript letters indicate a difference between the groups of P<0.05 using a Dunnett's test.

	PQQ treatment group
Parameter	PQQ+	PQQ−	PQQ+/−	PQQ−/+	LC
Body weight (g)	220±11^a	225±16^a	221±13^a	231±8^a	250±22^a
Liver/body weight (% relative to LC values)	96±5^a	82±4 ^b	101±4^a	91±4^a	100±5^a
Plasma PQQ (nM)	12±3^a	1.5±2.0^b	8±4^a	17±7^a	4.0±2.0^b
Liver mtDNA/nuclear DNA	1.05±0.24^a	0.76±0.13^b	0.82±0.2^a,b	1.3±0.2^a	1.1±0.2^a