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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Future Microbiol. 2010 May;5(5):749–758. doi: 10.2217/fmb.10.41

Figure 1. Summary of the known effects of neisserial porin PorB induced by its direct interaction with TLR2/TLR1 heterodimers on antigen-presenting cells.

Figure 1

B cells [67], dendritic cells [57] and macrophages [Unpublished Data] are all activated by PorB via TLR2. PorB induces NF-κB nuclear translocation and IkB degradation, which is not dependent on PTK or MAPK activity (in B cells) [67]. PorB does induce MAPK phosphoryaltion, but only Jnk is required for CD86 upregulation, p38 appears to be more important for TLR4-mediated induction of CD86 surface expression in macrophages. PTKs are involved in B-cell and macrophage proliferation [67], while MAPK and not PTK activity appears to be required for the induction of macrophage proinflammatory cytokine production, including IL-6, IL-12 and TNF.

NF: Nuclear factor; Por: Neisseria meningitidis protein; PTK: Protein tyrosine kinase; TLR: Toll-like receptors.