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. Author manuscript; available in PMC: 2010 Jul 21.
Published in final edited form as: Nat Rev Drug Discov. 2009 Jan;8(1):41–54. doi: 10.1038/nrd2760

Figure 3. structures of the two marketed gPcr allosteric modulators.

Figure 3

Cinacalet (compound 3) is a positive allosteric modulator of the calcium sensing receptor and is used to treat hyperparathyroidism. Maraviroc (compound 4) is a negative allosteric modulator of chemokine receptor 5 that inhibits HIV entry into cells and is used to treat HIV infections.