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. Author manuscript; available in PMC: 2010 Jul 21.
Published in final edited form as: Cancer Ther. 2009 Apr 14;7(A):254–267.

Figure 2.

Figure 2

Model for the functional roles of inflammatory chemokinesignaling in cancer. (A) Stromal and epithelial cells secrete inflammatory chemokines, contributing to the bioavailability of chemokinesin the local tisuemicroenvironment. Inflammatory chemokinesregulate autocrineand paracrinesignaling interactions between stromal and epithelial cells to regulate cellular proliferation, migration and invasion. (B) Expression of Inflammatory chemokinesin normal tissues, as demonstrated by CXC112 and CCL5 create a chemokinegradient which regulate homing of chemokinereceptor expressing cancer cells to other organs.