Table 2.

Targeted deletion of inflammatory chemokineand chemokinereceptors in mice

Gene	phenotype	citation
CCL2	diminished macrophage and TH1 T cell responses inexperimental autoimmune encephalomyelitis (EAE), no compensatory upregulation of CCR2 binding ligands	Huang et al, 2001
CCR2	decreased formation of lung granulomas induced by mycobacterium bovis, similar phenotype in EAE as ccl2-/-, decreased monocyte recruitment to inflamed tissues	Boring et al, 1997; Fife et al, 2000; Tsou et al, 2007
CCL5	defects in T cell proliferation, an overall reduction in T cell activation and recruitment in cutaneous delayed-type hypersensitivity assays	Makino et al, 2002
CCR5	decreased NK cell mobilization in mice infected with herpes simplex virus 2 leading to decreased survival, increased NK cell infiltration in experimental mouse model of colitis correlating with increased resistance to disease	Yamaoka et al, 1998; Andres et al, 2000; Thapa et al, 2007
CXCL1	artherosclerotic lesions leads to a reduction in macrophage recruitment associated with decreased lesion formation	Boisvert et al, 2006
CXCR2	decreased neutrophil recruitment and delayed wound healing responses, abnormal granulocyte differentiation, mice develop splenomegaly	Cacalano et al, 1994; Devalaraja et al, 2000
CXCL12	perinatal lethality, defects in B cell development in in fetal liver and bone marrow, reduction in myeloid progenitors in bone marrow, defects in cardiac development	Nagasawa et al, 1996
CXCR4	perinatal lethality due to multiple defects including decreased bone marrow cell and B cell development abnormal cerebellum morphology	Ma et al, 1998