Table 4.
Chemokine Target | Antagonist/Agonist | Cancer | Clinical Trial Status |
---|---|---|---|
CXCR4 | AMD3100 | Leukemia and Lymphoma | Phase II |
CXCL12 | CTCE-9908 | Late stage ovarian, breast, lung, colorectal, melanoma, gastric | Phase I/II |
CCL5 | Met-CCL5 | Breast Cancer | Pre-clinical |
CCR5 | TAK-779 | Multiple Myeloma, Prostate | Pre-clinical |
CXCR2 | AZ10397767 | Prostate | Pre-clinical |
SB225002 | Esophageal | ||
CCR2 | MLN1202 | Breast | Pre-clinical |