Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Sleepiness
Systematic review	178 people with OSAHS 4 RCTs in this analysis	Subjective sleepiness (Epworth Sleepiness Scale [ESS] score; see table 3 ) with automatically titrated CPAP with CPAP	WMD for ESS –0.43 95% CI –1.55 to +0.68 See further information on studies for methodological weaknesses		Not significant
Systematic review	154 people with OSAHS 5 RCTs in this analysis	Subjective sleepiness (ESS score) with automatically titrated CPAP with CPAP Absolute results not reported	WMD for ESS –0.36 95% CI –1.67 to +0.96 See further information on studies for methodological weaknesses		Not significant
Systematic review	154 people 5 RCTs in this analysis	Mean difference in sleepiness with automatically titrated CPAP with CPAP Absolute results not reported	mean difference in sleepiness –0.56 95% CI –1.4 to +0.3		Not significant
RCT Crossover design	46 people with severe OSAHS, mean baseline AHI 55	Sleepiness (mean change in ESS score) 7.9 with automatically titrated CPAP 8.4 with CPAP	Reported as not significant P value not reported		Not significant
RCT Crossover design	30 people with mean baseline AHI 41.1	Mean reduction in ESS score 1 month 6.1 with automatically titrated CPAP 6.1 with CPAP	Reported as not significant P value not reported		Not significant
RCT 3-armed trial	78 people with moderate to severe OSAHS; median >4% oxygen saturation dip rate of 34.5 dips/hour, range 10.3 dips/hour to 89.0 dips/hour	Reduction in ESS score 1 month 10 with automatically titrated CPAP plus CPAP 10.5 with CPAP 9 with automatically titrated CPAP alone Absolute results not reported	P = 0.9 (for among-group difference)		Not significant
Intermediate outcomes
Systematic review	277 people 6 RCTs in this analysis	AHI (see table 2 ) with automatically titrated CPAP with CPAP Absolute results not reported	WMD –0.34 95% CI –1.20 to +0.52 See further information on studies for methodological weaknesses		Not significant
Systematic review	154 people 5 RCTs in this analysis	Mean difference in AHI with automatically titrated CPAP with CPAP Absolute results not reported	mean difference in AHI –0.20 95% CI –0.74 to +0.35		Not significant
RCT Crossover design	30 people with mean baseline AHI 41.1	Mean reduction in AHI 1 month 36.5 with automatically titrated CPAP 35.7 with CPAP Absolute results not reported	P >0.05		Not significant
RCT Crossover design	30 people with mean baseline AHI 41.1	Mean reduction in oxygen desaturation index (ODI) 24.8/hour with automatically titrated CPAP 25.0/hour with CPAP	Reported as not significant P value not reported		Not significant
RCT 3-armed trial	78 people with moderate to severe OSAHS; median >4% oxygen saturation dip rate of 34.5 dips/hour, range 10.3 dips/hour to 89.0 dips/hour	Median AHI 1 month 4.2 with automatically titrated CPAP plus CPAP 4.4 with CPAP 5.8 with automatically titrated CPAP alone	P = 0.4		Not significant