Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Tinnitus loudness
RCT	120 people In review	Improvement in average pure tone 1.8 dB with paroxetine (10 mg/day, increased to maximum 50 mg/day for 100 days) 0.8 dB with placebo	P >0.05		Not significant
RCT	76 people with tinnitus considered to be at high risk of developing severe and disabling tinnitus	Reduction in tinnitus loudness score (measured by visual analogue scale; scale of 0–100 mm; higher score denotes louder levels of tinnitus) 16 weeks 15.21 with sertraline (25 mg/day for 1 week followed by 50 mg/day for 15 weeks) 3.21 with placebo	P = 0.013 The RCT may have been underpowered to detect a clinically meaningful difference between groups	Effect size not calculated	sertraline
Overall symptoms of tinnitus
RCT	76 people with tinnitus considered to be at high risk of developing severe and disabling tinnitus	Change in tinnitus severity questionnaire score (scale of 0–40; higher scores denote more severe tinnitus) 16 weeks 4.69 with sertraline (25 mg/day for 1 week followed by 50 mg/day for 15 weeks) 2.12 with placebo	P = 0.024 The RCT may have been underpowered to detect a clinically meaningful difference between groups	Effect size not calculated	sertraline