Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Tinnitus loudness
RCT	40 people In review	Proportion of people with improvement in tinnitus (measured by tinnitus synthesiser and visual analogue scale [scale of 0–10; increasing score is associated with increasing loudness]) 12 weeks 13/17 (77%) with alprazolam (initially 0.5 mg/night) 1/19 (5%) with placebo	Significance not assessed The RCT used dose adjustment of alprazolam but no dose adjustment of placebo, potentially biasing the results because of a difference in the attention given to people in the two groups