Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom improvement
Systematic review	345 people, 12 weeks, 1 study with a crossover design 2 RCTs in this analysis	Proportion of people achieving a marked response (at least 75% decrease in Psoriasis Area and Severity Index [PASI] score) with conventional oil-based ciclosporin formulation with microemulsion preconcentrate ciclosporin formulation Absolute results not reported			Not significant
Systematic review	People with psoriasis Data from 1 RCT	Proportion of people achieving a marked response (at least 75% decrease in PASI) 78% with conventional oil-based ciclosporin formulation 80% with microemulsion preconcentrate ciclosporin formulation Absolute numbers not reported	ARI +2% 95% CI –7% to +11%		Not significant