Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom improvement
Systematic review	123 people with severe psoriasis 2 RCTs in this analysis	AR for at least 70% reduction in Psoriasis Area and Severity Index (PASI) score 16 weeks with mixture of dimethylfumaric and monoethylfumaric acid esters with placebo Absolute results not reported	Pooled ARR 0.47 95% CI 0.33 to 0.61	Effect size not calculated	mixture of dimethylfumaric and monoethylfumaric acid esters
RCT	People with severe psoriasis In review	AR for at least 50% reduction in PASI score 27% with dimethylfumaric acid ester 0% with placebo Absolute numbers not reported	ARR 27% 95% CI 6% to 45%	Effect size not calculated	dimethylfumaric acid ester
RCT	People with severe psoriasis In review	AR at least 50% improvement in PASI score 16 weeks with monoethylfumaric acid ester with placebo Absolute results not reported	ARR –5% 95% CI –22% to +12%		Not significant