Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Skin reactions
RCT 4-armed trial	1603 people with chronic plaque psoriasis involving at least 10% of body surface	Local skin reactions 6% with calcipotriol plus betamethasone 11% with calcipotriol alone Absolute numbers not reported	OR 0.49 95% CI 0.31 to 0.70 P = 0.003	Moderate effect size	calcipotriol plus betamethasone
RCT 4-armed trial	1043 people with mild to moderate chronic plaque psoriasis involving at least 10% of body surface	Local skin reactions 30/304 (10%) with calcipotriol plus betamethasone 53/308 (17%) with calcipotriol alone	OR 0.53 95% CI 0.33 to 0.85 P = 0.008	Small effect size	calcipotriol plus betamethasone
RCT 3-armed trial	972 people with psoriasis affecting at least 10% of body surface	Skin reactions 35/322 (11%) with combined treatment (calcipotriol and betamethasone) 73/327 (22%) with calcipotriol alone	P <0.001	Effect size not calculated	calcipotriol plus betamethasone