Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Dyspeptic symptoms
Systematic review	2222 people with dyspeptic symptoms including those of GORD 5 RCTs in this analysis	Proportion of people with dyspeptic symptoms 264/836 (31%) with test-and-treat strategy 283/846 (33%) with endoscopy-based management	RR 0.95 95% CI 0.79 to 1.15 Calculated using random effects model Significant statistical heterogeneity among studies; see further information on studies for full details Results may not be generalisable to primary care; see further information on studies for full details		Not significant
Systematic review	1924 people with dyspeptic symptoms including those of GORD 5 RCTs in this analysis	Dyspeptic symptoms 1 year with test-and-treat strategy with endoscopy-based management Absolute results reported graphically	RR 0.95 95% CI 0.2 to 0.99 Individual patient data meta-analysis No heterogeneity among RCTs; see further information on studies for full details	Small effect size	endoscopy-based management
RCT 3-armed trial	234 people with dyspeptic symptoms	Decrease in mean dyspepsia severity score (assessed on a 12-item dyspepsia symptom severity score) 6 weeks 5.6 with empirical endoscopy 5.6 with eradication treatment 4.4 with empirical treatment with cisapride	Significance not assessed
RCT 3-armed trial	234 people with dyspeptic symptoms	Decrease in mean dyspepsia severity score (assessed on a 12-item dyspepsia symptom severity score) 1 year with empirical endoscopy with eradication treatment with empirical treatment with cisapride	Among-group difference reported as not significant P value not reported		Not significant
RCT 3-armed trial	722 people with dyspeptic symptoms Data from 1 RCT	Proportion of people who were asymptomatic 1 year 26% with test-and-eradicate strategy 23% with empirical proton pump inhibitor for 1 week 22% with empirical proton pump inhibitor for 1 week, plus, if symptoms improved, test-and-eradicate strategy as needed Absolute numbers not reported	Among-group difference reported as not significant P value not reported		Not significant