Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	1128 people 5 RCTs in this analysis	Adverse effects 34% with triple regimen 37% with quadruple regimen	OR 1.14 95% CI 0.76 to 1.7 P = 0.54 Updated meta-analysis reported here was published as a letter to the editor; results should be interpreted with caution		Not significant