Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT 3-armed trial	120 people with H pylori infection and dyspeptic symptoms or a history of peptic ulcer	Proportion of people reporting an adverse effect 16/35 (46%) with 7-day metronidazole-based regimen 19/39 (48%) with 7-day amoxicillin-based regimen	Significance assessment between groups not reported
RCT 3-armed trial	120 people with H pylori infection and dyspeptic symptoms or a history of peptic ulcer	Total number of adverse effects reported (could be >1 per person) 31 with 7-day metronidazole-based regimen 19 with 7-day amoxicillin-based regimen	P = 0.02	Effect size not calculated	amoxicillin-based regimen
RCT	1016 people with H pylori infection and active peptic ulcers or a history of peptic ulcer, 581 of whom received a triple regimen	Adverse effects with metronidazole-based regimens with amoxicillin-based regimens Absolute numbers not reported