Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Eradication rates
Systematic review	Number of people in analysis not reported	Eradication rates 80% with triple regimen with clarithromycin 250 mg twice daily (with proton pump inhibitor and amoxicillin) 90% with triple regimen with clarithromycin 500 mg twice daily (with proton pump inhibitor and amoxicillin) Absolute numbers not reported	RR 0.89 95% CI 0.81 to 0.97 NNT 11 95% CI 6 to 38	Small effect size	higher-dose clarithromycin (with amoxicillin)
Systematic review	Number of people in analysis not reported	Eradication rates 87% with triple regimen with clarithromycin 250 mg twice daily (with proton pump inhibitor and metronidazole) 89% with triple regimen with clarithromycin 500 mg twice daily (with proton pump inhibitor and metronidazole) Absolute numbers not reported	RR 0.98 95% CI 0.93 to 1.04		Not significant
RCT	288 people with H pylori infection and peptic ulcers	Eradication rates 116/143 (81%) with triple regimen using 200 mg clarithromycin twice daily (with omeprazole and amoxicillin) 116/145 (80%) with triple regimen using 400 mg clarithromycin twice daily (with omeprazole and amoxicillin)	Significance not assessed
RCT	189 people with gastric ulcers, all positive for H pylori Subgroup analysis	Eradication rates 88% with triple regimen with clarithromycin 200 mg twice daily (with lansoprazole and amoxicillin) 89% with triple regimen with clarithromycin 400 mg twice daily (with lansoprazole and amoxicillin)	Significance not assessed
RCT	188 people with duodenal ulcers, all positive for H pylori Subgroup analysis	Eradication rates 91.3% with triple regimen with clarithromycin 200 mg twice daily (with lansoprazole and amoxicillin) 84% with triple regimen with clarithromycin 400 mg twice daily (with lansoprazole and amoxicillin)	Significance not assessed
RCT	100 people with H pylori infection and a healed peptic ulcer or non-ulcer dyspepsia	Eradication rates 43/50 (86%) with 7-day triple regimen with clarithromycin 200 mg twice daily (with rabeprazole and amoxicillin) 47/50 (94%) with 7-day triple regimen with clarithromycin 400 mg twice daily (with rabeprazole and amoxicillin)	Reported as not significant P value not reported		Not significant