Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Eradication rates
Systematic review	906 people 7 RCTs in this analysis	Eradication rates 339/470 (72%) with 7-day treatment with proton pump inhibitor-based triple regimens 353/436 (81%) with 14-day treatment with proton pump inhibitor-based triple regimens	RR 0.89 95% CI 0.83 to 0.96 NNT 11 95% CI 7 to 33	Small effect size	14-day treatment
RCT 3-armed trial	909 people with H pylori infection and duodenal ulcer	Eradication rates 4 weeks 240/301 (80%) with 7-day treatment with proton pump inhibitor-based triple regimen 246/301 (82%) with 14-day treatment with proton pump inhibitor-based triple regimen	P = 0.53 The RCT adjusted results to allow for multiple comparisons		Not significant
RCT	598 people with H pylori infection and peptic ulcer disease	Eradication rates 5 weeks 240/337 (71%) with 7-day treatment with proton pump inhibitor-based triple regimen 197/261 (76%) with 14-day treatment with proton pump inhibitor-based triple regimen	ARR −4% 95% CI −11% to +3% RCT designed as an equivalence trial; the high predetermined non-inferiority margin of 15% means that the results must be treated with caution		Not significant
RCT	243 people with H pylori infection and dyspepsia having amoxicillin-based triple eradication therapy Subgroup analysis	Eradication rates 67/117 (57%) with 7-day treatment with amoxicillin-based triple regimen 88/126 (70%) with 14-day treatment with amoxicillin-based triple regimen	P = 0.05 Result is of borderline significance A multivariate analysis found that the 2-week duration of treatment was the only independent factor associated with a higher rate of H pylori eradication both at ITT and per-protocol analysis		Not significant
RCT	243 people with H pylori infection and dyspepsia having metronidazole-based triple eradication therapy Subgroup analysis	Eradication rates 63/122 (52%) with 7-day treatment with metronidazole-based triple regimen 68/121 (56%) with 14-day treatment with metronidazole-based triple regimen	Significance not assessed A multivariate analysis found that the 2-week duration of treatment was the only independent factor associated with a higher rate of H pylori eradication both at ITT and per-protocol analysis