Ref (type) | Population | Outcome, Interventions | Results and statistical analysis | Effect size | Favours |
Adverse effects | |||||
Systematic review |
Unclear |
Serious adverse effects
with allylamines with placebo Absolute results not reported |
Two RCTs included in the review reported an increase in liver enzymes with terbinafine cream 1% and with placebo, and one RCT reported neutropenia with placebo (results not reported). The adverse effects reported by RCTs in the review included burning, stinging, and itching sensations (further details not reported) |
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RCT |
324 people with interdigital tinea pedis |
Adverse effects
with terbinafine with placebo Absolute results not reported |
The RCT found no serious adverse effects associated with terbinafine 1% solution. Adverse effects reported included mild burning, moderate peripheral oedema, mild pain, and pruritus (further details not reported) |
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RCT |
84 people |
Adverse effects
with terbinafine 1% or 3% with placebo |
The RCT found no serious adverse effects associated with terbinafine 1% and 3% emulsion gel. Adverse effects reported included burning and stinging sensations, mild desquamation, erythema, and incrustation dryness (further details not reported) |