Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Wart clearance
RCT	24 adults with warts unsuccessfully treated for >3 months; matched pairs of warts on the left and right side of the body In review	Proportion of people with a more favourable response (not defined) 6 weeks 21/24 (88%) with bleomycin 0.1% 3/24 (13%) with saline placebo	P <0.001	Effect size not calculated	bleomycin 0.1%
RCT	24 adults with warts unsuccessfully treated for >3 months; matched pairs of warts on the left and right side of the body In review	Proportion of warts cured 6 weeks 34/59 (58%) with bleomycin 0.1% 6/59 (10%) with saline placebo	P <0.001	Effect size not calculated	bleomycin 0.1%
RCT	16 people In review	Proportion of warts cured 6 weeks 31/38 (82%) with bleomycin 0.1% 16/46 (34%) with placebo	P <0.001 Results should be interpreted with caution; RCT randomised number of people but analysed number of warts	Effect size not calculated	bleomycin 0.1%
RCT 4-armed trial	62 adults In review	Proportion of warts cured 3 months 4/22 (18%) with bleomycin 0.1% in saline 5/22 (23%) with bleomycin 0.1% in sesame oil 8/19 (42%) with saline placebo 5/11 (46%) with sesame-oil placebo	P = 0.018 for combined results for bleomycin v combined results for placebo Results should be interpreted with caution; RCT randomised number of people but analysed number of warts	Effect size not calculated	placebo
RCT	31 people In review	Proportion of people with wart clearance 30 days 15/16 (94%) with bleomycin 0.1% 11/15 (73%) with placebo	RR 1.28 95% CI 0.92 to 1.78		Not significant