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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Biomaterials. 2010 Mar 19;31(17):4639–4656. doi: 10.1016/j.biomaterials.2010.02.044

Table 2.

Enzyme-sensitive peptides (ESPs) that have been used for preparation of proteolytically degradable PEG hydrogels.

ESPa Origin Sensitive enzyme Monomer type Ref.
GPQG↓IAGQ Collagen-I MMP-1 Dithiol 161
GPQG↓IWGQ Peptide library MMP-1 Diacrylate 162
Dithiol 19,149,163–167
GPQG↓ILGQ Collagen-I MMP-1 Dialkyne 152
L↓GPA Peptide library MMP-1 Diacrylate 7,138,168–170
APG↓L Peptide library MMP-1 Diacrylate 171
YK↓NRD Fibrinogen Plasmin Dithiol 164,165
VR↓N Fibrinogen Plasmin Diacrylate 171
AAAAAAAAA Peptide library Elastase Diacrylate 138
AAPV↓RGGG Peptide library Elastase Monoacrylate 172
PEN↓FF Aggrecan MMP-13 Monothiol 153
a

↓ indicates the cleavage site.