Aging prolonged lipopolysaccharide (LPS)-induced deficits in locomotor activity, food intake, and body weight. Young adult and aged mice were injected i.p. with either saline or LPS and (a) locomotor activity, (b) food intake, and (c) body weight were measured at 0, 24, 48, and 72 h after LPS. Bars represent the mean ± SEM (n = 9). Means with different letters (a, b, c, or d) are significantly different (P<0.05) from each other. Bars denoted with the same letter (ie a) are equal to other bars denoted with the same letter (a) and are significantly different from bars denoted with different letters: (b), (c), or (d). Moreover, bars denoted with multiple letters (ie a, b) are significantly different only from bars denoted with a single different letter (c) and (d).