Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Hand function
RCT	122 people with systemic sclerosis and a history of a documented digital ulcer within the previous 12 months	Hand function (measured by modified Scleroderma Health Assessment Questionnaire [SHAQ]) 6 weeks with bosentan (125 mg twice daily) with placebo Absolute results reported graphically	P <0.005	Effect size not calculated	bosentan