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. 2008 Apr 21;84(1):319–325. doi: 10.1189/jlb.1107737

Figure 3.

Figure 3

IL-12 production by αDC1 or sDCs pulsed with or without tumor cells in (A) primary culture supernatant during generation of DCs and (B) after stimulation with CD40L-transfected J558 cells. The αDC1 showed significantly higher production of IL-12p70 than sDCs (P<0.001), and loading of tumor antigen onto αDC1 resulted in only mild suppression of IL-12 secretion, without eliminating the differences between αDC1 and sDCs. In both cases, the left-side panels represent the absolute levels of IL-12p70 (±sd of triplicate cultures) observed in a single representative experiment. The right-side panels represent the data from seven (B) to eight (A) CLL donors, expressed as a ratio of IL-12p70 production between αDC1 and sDCs generated from the same donor and matured in the same conditions (absence or presence of tumor material).