Fig. 7.

Model of regulation of the hDlg-PSF-RNA complex by the p38γ kinase. (A) Under normal physiological conditions, in resting cells, p38γ is localized mainly in the cytoplasm of the cell, whereas the hDlg-PSF-RNA complex is associated in the nucleus of the cell. (B) Changes in the osmolarity of the environment causes the accumulation of p38γ in the nucleus, which increases its binding to hDlg, The nuclear interaction of p38γ with hDlg through its PDZ domain 1 leads to hDlg dissociation from PSF and RNAs in the nucleus.