Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1961 Jun;40(6):903–913. doi: 10.1172/JCI104329

THE NATURE OF THE ACTION OF INTRAVENOUS ALDOSTERONE: EVIDENCE FOR A ROLE OF THE HORMONE IN URINARY DILUTION*

Edmund H Sonnenblick 1,, Paul J Cannon 1, John H Laragh 1
PMCID: PMC290806  PMID: 16695864

Full text

PDF
903

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUGUST J. T., NELSON D. H., THORN G. W. Response of normal subjects to large amounts of aldosterone. J Clin Invest. 1958 Nov;37(11):1549–1555. doi: 10.1172/JCI103747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARGER A. C., MULDOWNEY F. P., LIEBOWITZ M. R. Role of the kidney in the pathogenesis of congestive heart failure. Circulation. 1959 Aug;20(2):273–285. doi: 10.1161/01.cir.20.2.273. [DOI] [PubMed] [Google Scholar]
  3. BARNETT H. L., McNAMARA H. Electrolyte balances in a male infant with adrenocortical insufficiency and virilism; the effect of desoxycorticosterone acetate and salt therapy with special reference to potassium. J Clin Invest. 1949 Nov;28(6 Pt 2):1498–1506. doi: 10.1172/JCI102215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BARTTER F. C., DUNCAN L. E., Jr, LIDDLE G. W. The effect of changes in body sodium on extracellular fluid volume and aldosterone and sodium excretion by normal and edematous men. J Clin Invest. 1956 Nov;35(11):1299–1305. doi: 10.1172/JCI103385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BERLINER R. W. Ion exchange mechanisms in the nephron. Circulation. 1960 May;21:892–901. doi: 10.1161/01.cir.21.5.892. [DOI] [PubMed] [Google Scholar]
  6. BUCHT H., EK J., JOSEPHSON B., THOMASSON B., VARNAUSKAS E., WERKO L. Rapid infusion and renal function. Clin Sci. 1956 Nov;15(4):617–633. [PubMed] [Google Scholar]
  7. CONN J. W., LOUIS L. H. Primary aldosteronism, a new clinical entity. Ann Intern Med. 1956 Jan;44(1):1–15. doi: 10.7326/0003-4819-44-1-1. [DOI] [PubMed] [Google Scholar]
  8. DE WARDENER H. E., DEL GRECO F. The influence of solute excretion rate on the production of a hypotonic urine in man. Clin Sci. 1955 Nov;14(4):715–723. [PubMed] [Google Scholar]
  9. DINGMAN J. F., FINKENSTAEDT J. T., LAIDLAW J. C., RENOLD A. E., JENKINS D., MERRILL J. P., THORN G. W. Influence of intravenously administered adrenal steroids on sodium and water excretion in normal and Addisonian subjects. Metabolism. 1958 Sep;7(5):608–623. [PubMed] [Google Scholar]
  10. DOORENBOS H., ELINGS H. S., VAN BUCHEM F. S. Primary aldosteronism due to adrenocortical hyperplasia. Lancet. 1956 Aug 18;271(6938):335–337. doi: 10.1016/s0140-6736(56)92194-8. [DOI] [PubMed] [Google Scholar]
  11. GANONG W. F., MULROW P. J. Rate of change in sodium and potassium excretion after injection of aldosterone into the aorta and renal artery of the dog. Am J Physiol. 1958 Nov;195(2):337–342. doi: 10.1152/ajplegacy.1958.195.2.337. [DOI] [PubMed] [Google Scholar]
  12. GARROD O., DAVIES S. A., CAHILL G., Jr The action of cortisone and desoxycorticosterone acetate on glomerular filtration rate and sodium and water exchange in the adrenalectomized dog. J Clin Invest. 1955 Jun;34(6):761–776. doi: 10.1172/JCI103131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GOTTSCHALK C. W., MYLLE M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol. 1959 Apr;196(4):927–936. doi: 10.1152/ajplegacy.1959.196.4.927. [DOI] [PubMed] [Google Scholar]
  14. GREEN D. M., FARAH A., KLEMPERER W. W. Mechanisms of desoxycorticosterone action: renal effects of the water-soluble glycoside. Endocrinology. 1950 Oct;47(4):281–288. doi: 10.1210/endo-47-4-281. [DOI] [PubMed] [Google Scholar]
  15. HEINEMANN H. O., DEMARTINI F. E., LARAGH J. H. The effect of chlorothiazide on renal excretion of electrolytes and free water. Am J Med. 1959 Jun;26(6):853–861. doi: 10.1016/0002-9343(59)90207-4. [DOI] [PubMed] [Google Scholar]
  16. HUFFMAN E. R., WILSON G. M., Jr, CLARK G. M., SMYTH C. J. The acute renal effects of 9-alpha fluorohydrocortisone in human subjects with intact adrenals. J Lab Clin Med. 1956 May;47(5):747–751. [PubMed] [Google Scholar]
  17. JOHNSON B. B., LIEBERMAN A. H., MULROW P. J. Aldosterone excretion in normal subjects depleted of sodium and potassium. J Clin Invest. 1957 Jun;36(6 Pt 1):757–766. doi: 10.1172/JCI103480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KEKWICK A., PAWAN G. L. Oral aldosterone; effect in a case of Addison's disease. Lancet. 1954 Jul 24;267(6830):162–164. doi: 10.1016/s0140-6736(54)90138-5. [DOI] [PubMed] [Google Scholar]
  19. KLEEMAN C. R., EPSTEIN F. H., WHITE C. The effect of variations in solute excretion and glomerular filtration on water diuresis. J Clin Invest. 1956 Jul;35(7):749–756. doi: 10.1172/JCI103326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. KLEEMAN C. R., MAXWELL M. H., ROCKNEY R. E. Mechanisms of impaired water excretion in adrenal and pituitary insufficiency. I. The role of altered glomerular filtration rate and solute excretion. J Clin Invest. 1958 Dec;37(12):1799–1808. doi: 10.1172/JCI103773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LADD M. Effect of prehydration upon renal excretion of sodium in man. J Appl Physiol. 1951 Apr;3(10):603–609. doi: 10.1152/jappl.1951.3.10.603. [DOI] [PubMed] [Google Scholar]
  22. LARAGH J. H., ULICK S., JANUSZEWICZ V., DEMING Q. B., KELLY W. G., LIEBERMAN S. Aldosterone secretion and primary and malignant hypertension. J Clin Invest. 1960 Jul;39:1091–1106. doi: 10.1172/JCI104124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. LIDDLE G. W., CORNFIELD J., CASPER A. G., BARTTER F. C. The physiological basis for a method of assaying aldosterone in extracts of human urine. J Clin Invest. 1955 Sep;34(9):1410–1416. doi: 10.1172/JCI103190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MACH R. S., FABRE J., DUCKERT A., BORTH R., DUCOMMUN P. Action clinique et métabolique de l'aldostérone (electrocortine). Schweiz Med Wochenschr. 1954 Apr 10;84(15):407–416. [PubMed] [Google Scholar]
  25. ORLOFF J., WAGNER H. N., Jr, DAVIDSON D. G. The effect of variations in solute excretion and vasopressin dosage on the excretion of water in the dog. J Clin Invest. 1958 Mar;37(3):458–464. doi: 10.1172/JCI103625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. PRUNTY F. T., McSWINEY R. R., MILLS I. H., SMITH M. A. The effects of aldosterone in Addison's disease and adrenal pseudohermaphroditism. Lancet. 1954 Sep 25;267(6839):620–624. doi: 10.1016/s0140-6736(54)90402-x. [DOI] [PubMed] [Google Scholar]
  27. RAISZ L. G., MCNEELY W. F., SAXON L., ROSENBAUM J. D. The effects of cortisone and hydrocortisone on water diuresis and renal function in man. J Clin Invest. 1957 Jun;36(6 Pt 1):767–779. doi: 10.1172/JCI103481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. ROBERTS K. E., PITTS R. F. The influence of cortisone on renal function and electrolyte excretion in the adrenalectomized dog. Endocrinology. 1952 Jan;50(1):51–60. doi: 10.1210/endo-50-1-51. [DOI] [PubMed] [Google Scholar]
  29. ROEMMELT J. C., SARTORIUS O. W., PITTS R. F. Excretion and reabsorption of sodium and water in the adrenalectomized dog. Am J Physiol. 1949 Oct;159(1):124–136. doi: 10.1152/ajplegacy.1949.159.1.124. [DOI] [PubMed] [Google Scholar]
  30. ROSENBAUM J. D., NELSON W. P., 3rd, STRAUSS M. B., DAVIS R. K., ROSSMEISL E. C. Variation in the diurectic response to ingested water related to the renal excretion of solutes. J Clin Invest. 1953 May;32(5):394–404. doi: 10.1172/JCI102751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. SLESSOR A. Studies concerning the mechanism of water retention in Addison's disease and in hypopituitarism. J Clin Endocrinol Metab. 1951 Jul;11(7):700–723. doi: 10.1210/jcem-11-7-700. [DOI] [PubMed] [Google Scholar]
  32. THORN G. W., SHEPPARD R. H., MORSE W. I., REDDY W. J., BEIGELMAN P. M., RENOLD A. E. Comparative action of aldosterone and 9-alpha-fluorohydrocortisone in man. Ann N Y Acad Sci. 1955 May 27;61(2):609–619. doi: 10.1111/j.1749-6632.1955.tb42514.x. [DOI] [PubMed] [Google Scholar]
  33. VANDER A. J., MALVIN R. L., WILDE W. S., McMURRAY V. M., LAPIDES J., SULLIVAN L. P. Effects of adrenalectomy and aldosterone on proximal and distal tubular sodium reabsorption. Proc Soc Exp Biol Med. 1958 Nov;99(2):323–325. doi: 10.3181/00379727-99-24338. [DOI] [PubMed] [Google Scholar]
  34. WESSON L. G., Jr, ANSLOW W. P., Jr Effect of osmotic and mercurial diuresis on simultaneous water diuresis. Am J Physiol. 1952 Aug;170(2):255–269. doi: 10.1152/ajplegacy.1952.170.2.255. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES