Table 7.
Bazedoxifene | Raloxifene | Placebo | ||
---|---|---|---|---|
Parameter | 20 mg | 40 mg | 60 mg | |
Total cholesterol | ||||
No. of pairs | 1220 | 1201 | 1225 | 1248 |
Median percent change | -3.8b,c,d | -3.5b,c,d | -5.0b,c | 0.3 |
LDL cholesterol | ||||
No. of pairs | 1220 | 1201 | 1223 | 1247 |
Median percent change | -5.4b,c,d | -6.6b,c,d | -8.5b,c | 1.6b |
HDL cholesterol | ||||
No. of pairs | 1216 | 1196 | 1219 | 1246 |
Median percent change | 5.1b,c | 5.9b,c | 5.0b,c | 2.5b |
LDL/HDL cholesterol | ||||
No. of pairs | 1213 | 1191 | 1215 | 1244 |
Median percent change | -10.5b,c,d | -12.6b,c | -12.4b,c | -0.6 |
Triglycerides | ||||
No. of pairs | 1220 | 1201 | 1225 | 1248 |
Median percent change | 8.5b | 13.6b | 12.2b | 12.1b |
LDL, low-density lipoprotein; HDL, high-density lipoprotein.
aIncludes subjects in the intent-to-treat population (n = 6,847) with an assessment at baseline and at Month 36.
bP < 0.001 vs baseline; t test.
cP < 0.001 vs placebo; t test.
dP < 0.01 vs raloxifene 60 mg; t test.