Figure 1.

Everolimus penetrates the blood-brain barrier in R6/2 HD transgenic mice. Plasma (A) and brain (B) everolimus concentrations were measured 4 and 24 hours after the last dose following two weeks of treatment (black-bar = 10 μmol/kg, cross-hatched bar = 30 μmol/kg). Brain/plasma ratios (calculated as the ratio of brain to plasma concentration × 100) are higher than the reported [29] level of blood contamination (~6%) at 24, but not at 4 hours (C). Shown are mean ± SE. n = 3.