Table 3.
Association of HPV status with gender, age, tumor stage, alcohol and tobacco consumption
| Demographic | # Studies | HPV status | Smoking status | N | % |
|---|---|---|---|---|---|
| Tobacco | 17 | HPV+ | Ever | 1068 | 55.9 |
| Never | 948 | 44.1 | |||
| HPV- | Ever | 2179 | 74.5 | ||
| Never | 677 | 25.5 | |||
| Ethanol | 16 | HPV+ | Ever | 1548 | 66.8 |
| Never | 768 | 33.2 | |||
| HPV- | Ever | 2186 | 75.4 | ||
| Never | 713 | 24.6 | |||
| Stage | 10* | HPV+ | I-II | 78 | 26.7 |
| III-IV | 214 | 73.3 | |||
| HPV- | I-II | 259 | 42.8 | ||
| III-IV | 346 | 57.2 | |||
| LN Stage | 6 | HPV+ | N0 | 45 | 33.5 |
| N1-N3 | 123 | 66.5 | |||
| HPV- | N0 | 204 | 45.9 | ||
| N1-N3 | 240 | 54.1 | |||
| Gender | 18 | HPV+ | M | 1525 | 67.8 |
| F | 724 | 32.2 | |||
| HPV- | M | 2010 | 66.1 | ||
| F | 1033 | 33.9 | |||
| Median Age | 5** | HPV+ | 55 years | ||
| HPV- | 60 years | ||||
HPV: human papillomavirus; M: male; F: female; LN, lymph node; * 2 studies compared stage I-III vs. stage IV; ** 5 studies reported the median age of the subjects.