Table 2. IC50 values of biologically active oligosaccharides and FGFR and EGFR-2 inhibitors in endothelial cell migration assay.
Oligosaccharide/RTKi | FGF2 | VEGF165 | ||
µg/ml | µM | µg/ml | µM | |
8-mer 2SNS | 2.86 | 1.2 | ND | ND |
9-mer 2SNS | 2.11 | 0.83 | 9.17 | 3.6 |
10-mer 2SNS | 0.30 | 0.1 | 3.54 | 1.2 |
12-mer 2SNS | 0.38 | 0.11 | 0.58 | 0.17 |
PD173074 | - | 0.082 | ND | ND |
SU4312 | ND | ND | - | 0.19 |
The mean of at least two independent experiments is represented. No more than 2-fold differences between IC50s in two independent experiments were observed. ND - not determined; RTKi – receptor tyrosine kinase inhibitor.