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Biodistribution of vector genomes in tumor-bearing animals. HC-Ad vector genomes were quantified in the tissues indicated at 5 days after intratumoral injection of escalating doses of HC-Ad-TetOn-Flt3L and HC-Ad-TK (a, 5 × 108 vp; b, 1 × 109 vp; and c, 5 × 109 vp). The dotted line indicates the detection limit. Flt3L, fms-like tyrosine kinase ligand 3; HC-Ad, high-capacity adenovirus; TK, thymidine kinase.
