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Long-term survivors do not show evidence of neuropathology at 1 year after treatment. Neuropathological analysis was performed of the brains of the rats that were long-term survivors, at 1 year after intratumoral administration of escalating doses of HC-Ad-TetOn-Flt3L and HC-Ad-TK. Flt3L, fms-like tyrosine kinase ligand 3; HC-Ad, high-capacity adenovirus; MBP, myelin basic protein; MHC II, major histocompatibility complex II, TH, tyrosine hydroxilase; TK, thymidine kinase.
