TABLE 1.
Data Inputs for Model Variables
| Description (units) | Variable Name |
Median | Upper Limit (or SDa) |
Lower Limit | Source |
|---|---|---|---|---|---|
| COSTS ($US) | |||||
| Abdominal CT Scan | 1535.58 | 1013.48 | 2057.68 | 23 | |
| Hospitalization | 7517.54 | 242.95a | 14 | ||
| Metronidazole (IV) | 107.86 | 10.28a | 24 | ||
| Metronidazole (PO) | 60.90 | 39.28a | 24 | ||
| Peripheral Intravenous Line Insertion | 146.25 | 96.52 | 195.98 | 25 | |
| Surgery (Colectomy) | 15995.10 | 5412.71a | 14 | ||
| Vancomycin | 1184.90 | 782.03 | 1587.77 | 24 | |
| Vancomycin (Tapered) | 2221.70 | 1466.32 | 2977.07 | 24 | |
| UTILITIES (DALYs) | |||||
| 1st Recurrence | −0.0029 | −0.0039 | −0.0019 | 18 | |
| 2nd+ Recurrences | −0.0043 | −0.0058 | −0.0029 | 18 | |
| C. difficile Infection | −0.0014 | −0.0019 | −0.0009 | 18 | |
| Mortality | −14.00 | −18.76 | −9.24 | 18 | |
| PROBABILITIES (%) | |||||
| Given C. difficile colonization: | |||||
| Developing C. difficile infection | pInf | 26.15 | 25.69a | 26-29 | |
| Given C. difficile infection: | |||||
| Mortality | pDeath | 2.66 | 2.13a | 14, 30-32 | |
| Recurrence | pRec | 20.00 | 6.77a | 33-35 | |
| Severe Disease | pSevDis | 8.09 | 13.05a | 30, 36, 37 | |
| Mild Disease | 91.91b | b | 30, 36, 37 | ||
| Surgery (Colectomy) | pSur | 1.20 | 2.51a | 19, 30, 34, 38-42 |
|
| C. difficile treatment efficacies: | |||||
| Metronidazole | pEffTxMet | 90.41 | 9.28a | 43-50 | |
| Vancomycin | pEffTxVan | 98.18 | 7.64a | 45, 46, 48-53 |
|
| Vancomycin (Tapered) | pEffTxTap | 68.97 | 45.52 | 92.41 | 54 |
a
Standard deviation.
b
Probability of mild disease is calculated as 1 - pSevDis