Table 2. Annual rates of change (cm3) in relation to current PiB retention.
Longitudinal volume decline (interval effect), accompanied by ventricular CSF increase, was evident for all brain regions investigated. Main effects of PiB mean cortical DVR on regional brain volumes were not significant. No significant effects of mean cortical PiB on trajectories of age-related volume changes in the regions of interest were observed.
| Brain Volumes | Interval | PiB* | PiB × Interval |
|---|---|---|---|
| Whole Brain | -7.54 (0.3)* | -18.13 (22.5) | 0.29 (1.1) |
| vCSF | 1.13 (0.1)* | -5.62 (6.0) | -0.13 (0.29) |
| GM - Total | -2.64 (0.25)* | -8.77 (13.75) | -0.56 (1.01) |
| - Frontal | -0.86 (0.09)* | -1.27 (4.5) | 0.01 (0.36) |
| - Temporal | -0.33 (0.08)* | -2.94 (3.83) | -0.24 (0.33) |
| - Parietal | -0.72 (0.05) | -4.19 (3.33) | 0.02 (0.22) |
| - Occipital | -0.38 (0.05)* | 0.52 (2.86) | 0.08 (0.18) |
| WM - Total | -4.81 (0.24) | -2.17 (15.38) | 0.59 (0.99) |
| - Frontal | -2.07 (0.1)* | -1.26 (6.54) | 0.23 (0.41) |
| - Temporal | -1.73 (0.08)* | -0.11 (4.17) | 0.27 (0.31) |
| - Parietal | -0.39 (0.07)* | -3.93 (3.99) | 0.06 (0.27) |
| - Occipital | -0.21 (0.06)* | 0.89 (2.31) | -0.13 (0.23) |
| Hippocampus | -0.02 (0.01)* | -0.21 (0.28) | -0.01 (0.02) |
| OFC | -0.07 (0.02)* | -1.01 (1.01) | -0.02 (0.07) |
| Cingulate Gyrus | -0.2 (0.02)* | 0.03 (1.25) | -0.07 (0.09) |
| Precuneus | -0.04 (0.01)* | 0.34 (0.41) | -0.04 (0.02) |
Results are expressed as β-coefficients (SE).
PiB = mean cortical DVR; OFC = Orbito-frontal Cortex
*
PiB mean cortical DVR is an average of orbito-frontal, prefrontal, superior frontal, parietal, temporal, occipital, and anterior and posterior cingulated regions.
*
p < 0.05