Skip to main content
. Author manuscript; available in PMC: 2010 Jul 22.
Published in final edited form as: Eur J Clin Pharmacol. 2009 May 14;65(7):667–678. doi: 10.1007/s00228-009-0660-5

Table 2.

Distribution of the genetic polymorphisms within each ethnic group and P-values for the Hardy-Weinberg proportions test (H-W)

Number of patients (%) H-W P-value
African
ABCB1 exon 26 (CC/CT/TT) 11 (55)/9 (45)/0 (0) 0.43
ABCB1 exon 21 (GG/GT/TT) 19 (95)/1 (5)/0 (0) 0.99
CYP3A5 (4 *1/3 *1/≤2 *1) 0 (0)/8 (40)/12 (60) 0.53
CYP3A4*1B (*1A*1A/*1A*1B/*1B*1B) 9 (45)/8 (40)/3 (15) 0.86
Caucasian
ABCB1 exon 26 (CC/CT/TT) 2 (12)/12 (70)/3 (18) 0.22
ABCB1 exon 21 (GG/GT/TT) 4 (21)/11 (58)/4 (21) 0.79
CYP3A5 (4 *1/3 *1/≤2 *1) 18 (100)/0 (0)/0 (0) 1
CYP3A4*1B (*1A*1A/*1A*1B/*1B*1B) 0 (0)/3 (16)/16 (84) 0.93

Note: One patient had missing information for all genotypes, ABCB1 exon 26 and CYP3A4 genotypes were also both missing in another patient, in addition one patient had missing genotype for ABCB1 exon 26