Fig. 3.

Platinum susceptibility single-nucleotide polymorphisms (SNPs) of interest may function through regulation of a common target gene family. (a) In Asians (ASN), an example SNP of interest derived from the cisplatin analysis (left panel) and one derived from the carboplatin analysis (right panel) are each associated with the differential expression of a member of the histone H3 family of genes (HIST1H3A and HIST1H3I). Baseline histone H3 expression is plotted as a function of genotype for each SNP. (b) ASN cisplatin and carboplatin IC₅₀s are plotted separately as a function of expression for the respective target histone H3 genes. The cytotoxicity phenotypes for both drugs were correlated with histone H3-member expression levels.