Fig. 4. Recognition of HA by 6.5+CD4+ T cells drives arthritis in TS1×HACII mice.

(A) Graph indicates the largest ankle widths from individual 9 to 13 week-old TS1.RAG−/− (open bars) and TS1×HACII.RAG−/− (filled bars) mice. The mean ankle width of TS1×HACII.RAG−/− mice is significantly greater than that of TS1.RAG−/− mice (P<0.01). (B) Picture shows H&E stained wrist section from an arthritic TS1xHACII.RAG−/− mouse. p, pannus.