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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Immunol Rev. 2010 Jan;233(1):97–111. doi: 10.1111/j.0105-2896.2009.00848.x

Fig. 9. Steps where regulatory T-cell activity may shape arthritis development in TS1×HACII mice.

Fig. 9

Step 1, Deletion/Treg cell formation among autoreactive 6.5+CD4+ thymocytes. Step 2, Lymphopenia-induced proliferation of 6.5+CD4+ T cells secondary to severe thymocyte deletion. Step 3, reciprocal activation of HA-specific CD4+ T cells by HA-expressing antigen presenting cells. Step 4, activation of B cells by HA-specific CD4+ T cells. Step 5, spontaneous differentiation and cytokine production by autoreactive HA-specific CD4+ T cells. Step 6, development of a regional immune response in the lymph nodes that drain the major joints.